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Table 1 Incidences of malignant mesotheliomas, mean survival times of morbid mesothelioma-bearing rats, and first day of mesothelioma detection

From: The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats

Substance Length (μm) WHO fibers* Diameter (μm) WHO fibers* Dose WHO fibers* 109per rat (actual##) No. of rats Rats with mesothelioma Mean survival time of mesothelioma-bearing rats (days) Month of first detection of a morbid mesothelioma-bearing rat Final month**
Medium control - - - 50 1 (2%) 739 24 24
MWCNT A low 8.57 ± 1.51 0.085 ± 1.60 0.48 50 49 (98%) 213 5 9
MWCNT A high 2.39 50 45 (90%) 194 5 8
MWCNT B low 9.30 ± 1.63 0.062 ± 1.71 0.96 50 46 (92%) 294 6 13
MWCNT B high 4.80 50 45 (90%) 207 5 9
MWCNT C low 10.24 ± 1.64 0.040 ± 1.57 0.87 50 42 (84%) 415 10 18
MWCNT C high 4.36 50 47 (94%) 265 6 11
MWCNT D low 7.91 ± 1.40 0.037 ± 1.45 1.51 50 20 (40%) 666 20 24
MWCNT D high 7.54 50 35 (70%) 585 11 24
Long amosite asbestos 13.95 ± 2.10 0.394 ± 1.83 0.14 50 33 (66%) 623 14 24
  1. *WHO fibers: length greater than 5 μm, diameter less than 3 μm, and a length-to-width ratio (aspect ratio) of at least 3:1.
  2. ##Actual WHO fiber number dose; deviations from target values are due to inhomogeneities during successive synthesis or suspension of test items.
  3. **Last month when a mesothelioma-bearing rat was found in a group.