Role of microbial and chemical composition in toxicological properties of indoor and outdoor air particulate matter

Happo, Mikko S; Sippula, Olli; Jalava, Pasi I; Rintala, Helena; Leskinen, Ari; Komppula, Mika; Kuuspalo, Kari; Mikkonen, Santtu; Lehtinen, Kari; Jokiniemi, Jorma; Hirvonen, Maija-Riitta

doi:10.1186/s12989-014-0060-6

Table 4 Association between inorganic soluble chemical constituents, polyaromatic hydrocarbons (PAHs) and microbes in PM _10–2.5 and PM _2.5–0.2 size ranges separately and the inflammatory and cytotoxic response markers in mouse macrophages after exposure to three different doses of particles (50, 150 and 300 μg/ml) for 24 h

From: Role of microbial and chemical composition in toxicological properties of indoor and outdoor air particulate matter

		PM_10–2.5						PM_2.5–0.2
		n	MTT	PI	SubG₁	TNFα	MIP2	n	MTT	PI	SubG₁	TNFα	MIP2
PC1	Al	24	.474*	.435*	0.256	.776*	.805**	24	.690**	.577**	0.153	.661**	.635**
	Ca	24	.583**	.503*	.453*	.687**	.763**	24	.810**	.673**	.430*	.623**	.684**
	Fe	21	0.612**	.605**	0.396	.743**	.714**	24	.444*	0.337	−0.043	.542**	.471*
	K	24	.784**	.734**	.564**	.878**	.875**	24	.667**	.572**	0.316	.463*	.489*
	Mg	24	.525**	.503*	0.329	.775**	.810**	24	.863**	.819**	.425*	.717**	.754**
	Na	24	.544**	.498*	0.323	.740**	.790**	24	.823**	.649**	0.352	.613**	.642**
	Ni	24	.619**	.560**	0.396	.806**	.802**	24	.573**	.438*	0.216	0.385	0.388
PC2	SO₄	24	.695**	.643**	.668**	0.287	0.343	24	.711**	.487*	0.332	.454*	.463*
	NO₃	24	0.32	0.354	0.281	0.303	0.402	21	.606**	.451*	0.399	0.248	0.264
	V	24	.556**	.536**	.483*	.465*	.500*	24	.607**	.454*	.423*	0.244	0.29
	Zn	24	.688**	.593**	.597**	.648**	.692**	24	.771**	.657**	.503*	.501*	.557**
	TotalPAH	24	0.358	0.298	.519**	0.018	0.13	24	0.379	0.083	0.343	−0.064	−0.011
PC3	Cl	24	.444*	0.35	.553**	0.136	0.242	24	.776**	.575**	.453*	.518**	.586**
	F	18	.889**	.769**	.957**	0.176	0.271	21	.775**	.604**	.548*	0.373	.457*
	Cu	24	.624**	.573**	.423*	.790**	.806**	24	.751**	.814**	.502*	.618**	.654**
PC4	Universal bacterial assay	24	.921**	.890**	.781**	.713**	.680**	24	.634**	0.317	0.159	0.403	.494*
Other	Genotoxic PAH	24	0.393	0.345	.538**	0.062	0.168	24	.406*	0.109	0.365	−0.038	0.017
	EUPah	24	.414*	0.364	.609**	−0.002	0.096	24	0.401	0.108	0.355	−0.02	0.034
	Penicillium sp./Aspergillus sp	24	.786**	.816**	.737**	.609**	.611**	24	.503*	0.3	0.089	.429*	.479*
	Cladosporidium cladosprioid	24	.603**	.729**	0.337	.857**	.835**	21	.734**	0.416	0.294	.487*	.497*
	Streptomyces sp.	21	.765**	.755**	.832**	0.19	0.17	18	.571*	.511*	0.302	0.42	0.437
	Mycobacterium sp.	24	.878**	.891**	.733**	.810**	.814**	15	.654**	.529*	0.504	0.474	.565*

The values are Spearman correlation coefficients (ρ), (** p < 0.01, * p < 0.05).
Genotoxic PAH compounds according to WHO (1998).
EU PAH compounds according to the EU Directive 2004/107/EC.

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ISSN: 1743-8977

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