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Table 2 IC 50 values related to exposure to Ag ENMs for Relative growth activity (RGA) and Plating efficiency (PE) assays in A549 cells (Time of exposure 2, 24, 48 h)

From: Is the toxic potential of nanosilver dependent on its size?

  

Ag ENMs 50 nm

Ag ENMs 80 nm

Ag ENM 200 nm

Relative growth activity

    

[μg/cm2]

T = 2 h

16.8 ± 1.71

24.42 ± 1.82

23.68 ± 1.51

T = 24 h

23.68 ± 11.42

37.53 ± 17.58

36.37 ± 12.84

T = 48 h

15.94 ± 1.33

26.09 ± 11.63

21.71 ± 7.41

[ENMs × 1011/cm2]

T = 2 h

6.57 ± 0.6

2.51 ± 0.19

0.46 ± 0.03

T = 24 h

9.26 ± 4.47

3.86 ± 1.81

0.75 ± 0.25

T = 48 h

6.23 ± 0.52

2.69 ± 1.2

0.42 ± 0.14

[ENMs cm2/cm2]

T = 2 h

2.3 ± 0.23

1.85 ± 0.13

0.61 ± 0.53

T = 24 h

3.24 ± 1.33

2.84 ± 1.33

1.41 ± 0.5

T = 48 h

2.18 ± 0.18

1.97 ± 0.88

0.84 ± 0.29

Plating efficiency

    

[μg/cm2]

T = 2 h

35.58 ± 13.7

-

-

T = 24 h

31.65 ± 15.81

31.65 ± 15.81

-

T = 48 h

17.83 ± 4.5

14.25 ± 1.94

-

[ENMs × 1011/cm2]

T = 2 h

13.91 ± 5.35

-

-

T = 24 h

12.37 ± 6.18

3.66 ± 0.41

-

T = 48 h

6.97 ± 1.77

1.48 ± 0.2

-

[ENMs cm2/cm2]

T = 2 h

4.87 ± 1.89

-

-

T = 24 h

4.37 ± 2.17

2.69 ± 0.3

-

T = 48 h

2.44 ± 0.62

1.08 ± 0.15

-

  1. -IC50 could not be estimated. IC50 values were calculated for 3 different concentration characterization units: number of ENMs (ENMs × 1011/cm2), surface area of ENMs (ENMs cm2/cm2) and mass of ENMs (μg/cm2) per exposure surface.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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