Skip to main content
Figure 1 | Particle and Fibre Toxicology

Figure 1

From: Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

Figure 1

Experimental design. C57Bl/6j mice were intranasally instilled with silica nanoparticles (5 mg/Kg) or vehicle and 5 h post NPs instillation infected with P.aeruginosa by intranasal instillation. 18 h after infection, inflammatory markers in the lungs were analysed by measuring cytokines and neutrophil recruitment in the broncho-alveolar lavages (BALs). Bacterial loads were studied by bioluminescence after infection with a Pa-luciferase producing strain. Distribution of fluorescently labelled FITC SiO2 NPs (Fate of NPs) was followed by immunofluorescence analysis of cells present in BALs and lung tissues.

Back to article page

Particle and Fibre Toxicology

ISSN: 1743-8977

Contact us