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Table 2 Alveolar surface areas in rats and humans (the toxicological study [17] applied in model A used Fischer rats F344)

From: Translational toxicology in setting occupational exposure limits for dusts and hazard classification – a critical evaluation of a recent approach to translate dust overload findings from rats to humans

  Species/strain N Method and comments Lung function status* Alveolar surface area: absolute values Alveolar surface area: ratio human/rat
Yeh [23] Rat (Long Evans, 330 g) 1 silicone rubber cast (does not entail the alveolar region) TLC 0.5725 m2 (mentioned as calculated value on p. 487, no value given in Table Two) - -
Yeh & Schum [24] Human (60 years, ♂) 1 silicone rubber cast (does not entail the alveolar region) TLC No value given (neither in the text nor in Table Two) - -
US EPA [21]Brown et al. [5] Rat (authors reference Yeh et al. [23], scaled to FRC) human (authors reference Yeh and Schum [24], scaled to FRC) 1 silicone rubber cast (does not entail the alveolar region) derivation of values in Brown et al. [5] cannot be reproduced from Yeh et al. [23] and Yeh and Schum [24] because of missing data and an unknown algorithm FRC 0.2972 m2 193 (57.22/ 0.2972)  
1 FRC 57.22 m2
Gehr et al. [27] Human (19 – 40 J) 8 in situ instillation with glutaraldehyde solution, evaluation by electron microscopy (evaluation according to the reference method, Hsia et al. [26]) TLC 143 m2 ± 12   349 (143 acc. to Gehr/0.41 acc. to Stone) (identical methods and F344 rats)
Stone et al. [28] Rat (F344, 290 g) 4 in situ instillation with glutaraldehyde solution, evaluation by electron microscopy (evaluation according to the reference method, Hsia et al. [26]) TLC 0,41 m2 ± 0,04 249 (102,2/ 0,4)
0.4 m2 ± 0,03
Rat (SD, 363 g) 8
Human (nonsmoker) 4 (3♀, 1♂) surgically resected lung lobes (no in situ instillation, underestimation probable because of post-mortal atalectasis)   102.2 m2 ± 20,5
  1. *TLC: total lung capacity, FRC: functional residual capacity.