Table 7 Comparison of initial cellular and molecular events after lung particle exposure in different experimental animals leading to pre-tumour conditions: DNA damage, p53 activation and proliferation
Phase # | Parameter | Animals compared; model used | comparison | Source |
|---|---|---|---|---|
Phase 1 | PMN | BALF; rat mouse hamster | R >> > M, H | Carter and Driscoll [156] |
Carter et al. [157] | ||||
Phase 1 | PMN | BALF; rat, hamster | R >> > H | Seiler et al. [158] |
Phase 1 | MIP2, TNF alpha | BALF AM; rat mouse, hamster | R >> > H, M | Carter and Driscoll [156] |
Carter et al. [157] | ||||
Phase 2 | IL-10 | Rat, mouse hamster | R, M < << H | Carter et al. [157] |
Phase 2 | GSH level in BALF | Rat vs. hamster | R >> > H | Seiler et al. [158] (it 90d) |
Phase 3 | Repair: Indirect hint by in vitro studies of the ionizing radiation induced DNA damage (Human vs murine cells),with regard to the species-specific reaction to particles differences in repair capacities are not investigated | Behrens et al. [159] | ||
Phase 4 | 8-oxogua | Tissue; rat vs. hamster | R >> > H | Seiler et al. [158] |
Phase 4 | P53 Mutation in tissue | Tissue; rat vs. hamster | R > H | Seiler et al. [158] |
Phase 4 | proliferation | Tissue; rat vs. hamster | R >> > H | Seiler et al. [158] |
Carter and Driscoll [156] | ||||