Fig. 4

Exposure to CAP induces reversible cardiac dysfunction. a, the ratio of heart weight to body weight of SHR after 15 weeks of exposure to CAP (week 20). *p < 0.05 vs FA, student’s t test. n = 6/group. b and c, the cardiac protein levels of hypertrophic markers, ACTA1, MYH7, and SERCA2 after 15 weeks of exposure to CAP (week 20), as analysed by western blot. Representative images (b) and the summary (c) are presented. *p < 0.05 vs FA, one way ANOVA. D, the ratio of heart weight to body weight of SHR 5 weeks of withdrawal from CAP exposure (week 25). *p < 0.05 vs FA, student’s t test. n = 6/group. d and e, the cardiac protein levels of hypertrophic markers, ACTA1, MYH7, and SERCA2 5 weeks of withdrawal from CAP exposure (week 25), as analysed by western blot. Representative images (d) and the summary (e) are presented. *p < 0.05 vs FA, one way ANOVA