Table 1 Particulate matter effects on gene expression of angiotensin and bradykinin systems in the lungs. Semi-quantitative expression results of angiotensin-receptor type-2 (At2r), bradykinin receptor type-1 (B1r) and type-2 (B2r), and kallikrein (Klk-1) enzyme after acute and subchronic exposures

Group

FA

CP

FP

UFP

Gene

At2r

1

1.3

1.85

1.32

(0.6-1.4)

(0.61-2.17)

(1.1-2.5)

(0.5-1.9)

B1r

1

1.05

1.3

1.08

(0.9-1.1)

(0.8-1.2)

(1.01-2)

(0.9-1.1)

B2r

1.1

1.1

2

1.4

(0.6-1.2)

(0.9-1.77)

(0.9-3.1)

(1.4-1.7)

Klk-1

1

1.12

1.88 *

1.43 *

(0.94-1.1)

(0.76-1.3)

(1.4-2)

(1.1-2.35)

Group

FA

CP

FP

UFP

Gene

At2r

1

0.73

0.85

0.82

(0.8-1.15)

(0.7-1.1)

(0.5-1.1)

(0.6-1.1)

B1r

1

0.95

1.

1

(0.9-1.2)

(0.9- 1.03)

(0.94-1.5)

(0.93-1.1)

B2r

1

1.03

1.6

1

(0.9-1.2)

(1-1.2)

(1.15-4.2)

(0.93-1.1)

Klk-1

1

0.84

1.78

0.92

(0.8-1.2)

(0.8-1.1)

(0.7-2.7)

(0.9-1.4)