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Table 5 Biochemistry parameters in the BALF of male and female rats 24 h and 90 days after a 90-day exposure to Graphistrength© C100

From: Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats

Concentration (mg/m3) Phospholipids mmol/L LDH U/L ALP U/L GGT U/L Protein mg/L
MALE
24 h post exposure
0 0.16 196.8 37.6 5.9 92.7
0.05 0.21 168.6 38.8 6.7 84.2
0.25 0.36* 275.4 64.7 12.5** 115.4
5.0 1.05** 1306.2** 195.4** 19.5** 395.0**
90 days post exposure
0 0.26 225.7 76.4 5.6 115.4
0.05 0.27 174.8 78.2 6.3 79.8
0.25 0.42 237.2 108.5 9.5 102.3
5.0 1.18** 1353.2** 330.3** 16.1** 347.4**
FEMALE
24 h post exposure
0 0.17 163.6 34.9 5.1 78.8
0.05 0.18 163.0 28.8 6.6 91.2
0.25 0.30 312.7 63.4 12.5** 146.4
5.0 0.82** 1020.2** 144.1** 15.9** 292.6**
90 days post exposure
0 0.23 147.9 55.2 5.0 103.5
0.05 0.22 159.0 45.3 4.8 90.8
0.25 0.31 194.5 63.0 7.8 103.5
5.0 0.76** 566.2** 117.8** 15.8** 300.2**
  1. * p < 0.05, ** p < 0.01; statistical significant differences to controls