Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area

Table 1 Pearson correlations for biological potency and particle constituents across size fractions in J774A.1 and A549 cell models

	Metals							Polycyclic aromatic hydrocarbons							Endotoxin
	J774 cells				A549 cells			J774 cells				A549 cells			J774 cells				A549 cells
Size	LDH	ATP	RES	CYT	LDH	ATP	RES	LDH	ATP	RES	CYT	LDH	ATP	RES	LDH	ATP	RES	CYT	LDH	ATP	RES
UFP	0.68	−0.24	−0.34	−0.72	−0.55	−0.21	0.38	−0.65	0.15	−0.17	0.79	−0.61	−0.54	−0.49	0.08	−0.23	−0.27	0.87	−0.03	0.07	−0.35
PM_0.1–0.5	0.00	−0.18	−0.68	0.23	−0.32	0.26	−0.09	−0.68	0.46	−0.36	0.64	−0.89	0.52	−0.40	0.02	0.43	−0.27	0.67	0.14	−0.04	−0.60 ^*
PM_0.5–2.5	0.56	−0.38	−1.00 ^*	0.15	−0.30	0.86 ^**	−0.75	−0.17	0.26	−0.68	0.01	−0.47	0.93 ^*	−0.59	0.19	0.39	0.54 ^*	0.27	−0.44 ^**	0.28	0.37
PM_2.5–10	−0.13	0.02	−1.00 ^*	−0.42	−0.16	0.30	−0.83 ^**	−0.05	−0.46	−0.44	0.37	0.17	−0.31	−0.28	0.54 ^*	0.49 ^**	0.26	0.49	0.09	0.55 ^*	−0.15
ALL	0.23	−0.16	−0.60 ^*	0.44 ^**	−0.07	−0.15	−0.43 ^**	0.32	−0.15	−0.26	0.63 ^*	0.28	−0.24	−0.29	0.70 ^*	0.21 ^**	−0.06	0.89 ^*	0.72*	0.73 ^*	0.31 ^*

Particle potency was assessed by lactate dehydrogenase (LDH) release, intracellular ATP, resazurin (RES) reduction, and cytokine (CYT) release after 24 h exposure
UFP ultrafine particles, ALL regressions performed on data for all size fractions
^* p < 0.05
^** p < 0.1

ISSN: 1743-8977