Fig. 6
Plasma markers of ROS and RNS formation. Mean fold-effect ± SEM. a. m-Tyrosine, not significant. b. o-Tyrosine. 3-way ANOVA, Ozone × EHC-93, p = 0.025. Tukey, *0 vs 0.8 ppm O3 within 0 mg/m3 EHC-93, #0 vs 50 mg/m3 EHC-93 within 0 ppm O3, p < 0.05. 2-way ANOVA, Ozone × EHC-93, p = 040. Tukey, †0 vs 0.4 ppm O3 within 50 mg/m3 EHC-93, p < 0.05. c. p-Tyrosine. 3-way ANOVA, EHC-93, p < 0.001 and Ozone × Recovery, p < 0.001. Tukey, *0 vs 50 mg/m3 EHC-93, #0 vs 0.8 ppm O3 within 24 h, †0 vs 0.8 ppm O3 within 0 h recovery, p < 0.05. 2-way ANOVA, EHC-93, p = 0.010. Tukey, *0 vs 50 mg/m3 EHC-93, p < 0.05. d. 3-Nitrotyrosine. 3-way ANOVA, Ozone × EHC-93, p = 0.026. Tukey, *0 vs 0.8 ppm O3 within 0 mg/m3 EHC-93, #0 vs 50 mg/m3 EHC-93 with 0 ppm O3, p < 0.05. 2-way ANOVA, EHC-93, p = 0.035. Tukey, †0 vs 50 mg/m3 EHC-93, p < 0.05. e. 3-Nitrotyrosine/L-Dopa. 3-way ANOVA, EHC-93, p = 0.044. Tukey, *0 vs 50 mg/m3 EHC-93, p < 0.05. 2-way ANOVA, Ozone, p = 0.029. Tukey, #0.4 vs 0.8 ppm O3, p < 0.05. For detailed statistics, refer to Additional files 5 & 7. (Sample size, n = 7–8/air pollutant exposure group; n = 14/air control group)