Fig. 5
HE and TUNEL staining of lung tissues harvested from mice exposed to Al2O3 NPs. a HE staining of control mice lung tissue b) arrows showed pneumorrhagia in lung tissue from 2 mg/m3 Al2O3 NP exposure c) arrows demonstrated lymphocytes infiltration of lung tissue due to exposure to 10 mg/m3 Al2O3 NPs d) few apoptosis cells were observed in control mice lung tissue by TUNEL staining e) massive apoptosis in bronchial epithelia were induced by 10 mg/m3 Al2O3 NP exposure as shown by arrows f) ALCAR supplement reduced apoptosis of bronchial epithelia in 10 mg/m3 Al2O3 NP exposed mice lung tissue. The arrows show apoptotic epithelial cells. g The pathological lesion score of mice lung tissues h) Proportion of TUNEL-positive bronchial epithelia within each group. * P < 0.05, compared with untreated control. # P < 0.05, compared with corresponding control