Table 1 Comparative summary of data from experiments using I.T. instillation (in vivo), I.V. injection (in vivo) and cultured endothelial cells (in vitro)
| Â | Â | Â | Particulate | ||
|---|---|---|---|---|---|
| Â | Â | Time (hours) | DEP | CB | DQ12 |
I.T. instillation | Pulmonary cells | 2 | NSD | ------ | ------ |
(In vivo) |  | 6 | ↑ | ↑↑ | ↑↑ |
| Â | Â | 24 | NSD | ------ | ------ |
|  | Pulmonary IL-6 | 6 | ↑ | ↑ | NSD |
|  | Pulmonary TNFα | 6 | NSD | NSD | NSD |
|  | Pulmonary CRP | 6 | NSD | ↑↑ | ↑↑ |
| Â | Plasma IL-6 | 6 | NSD | NSD | NSD |
|  | Plasma TNFα | 6 | NSD | NSD | NSD |
|  | Plasma CRP | 6 | NSD | ↑↑ | ↑↑ |
| Â | Thrombosis | 2 | NSD | ------ | ------ |
|  |  | 6 | ↑ | NSD | NSD |
| Â | Â | 24 | NSD | ------ | ------ |
|  | tPA:PAI-1 | 6 | ↓↓ | ↓↓ | ↓↓ |
|  | PMA |  | ↑↑ | NSD | NSD |
I.V. injection | Pulmonary cells | 2 | NSD | ------ | ------ |
(In vivo) | Â | 6 | NSD | NSD | ------ |
| Â | Â | 24 | NSD | ------ | ------ |
| Â | Pulmonary IL-6 | 2 | L.O.D | L.O.D. | ------ |
|  | Pulmonary TNFα | 2 | NSD | NSD | ------ |
| Â | Pulmonary CRP | 2 | NSD | NSD | ------ |
| Â | Plasma IL-6 | 2 | NSD | NSD | ------ |
|  | Plasma TNFα | 2 | NSD | NSD | ------ |
|  | Plasma CRP | 2 | NSD | ↑↑ | ------ |
|  | Thrombosis | 2 | ↑ | ------ | ------ |
| Â | Â | 6 | NSD | NSD | ------ |
| Â | Â | 24 | NSD | ------ | ------ |
|  | tPA:PAI-1 | 6 | ↓↓ | ↓↓ | ------ |
|  | PMA | 24 | ↑ | NSD | ------ |
Cultured HUVECs | tPA transcripts | Basal | ↓ | ------ | ------ |
In vitro | Â | Stimulated | NSD | ------ | ------ |
| Â | PAI-1 transcripts | Basal | NSD | ------ | ------ |
|  |  | Stimulated | ↓ | ------ | ------ |
| Â | tPA antigen | 6 | NSD | ------ | ------ |
|  |  | 24 | ↓↓ | ------ | ------ |
|  | PAI-1 activity | 6 | ↓↓ | ------ | ------ |
|  |  | 24 | ↓↓ | ------ | ------ |