Fig. 3
From: Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways
Micronuclei formation in BEAS-2B cells upon exposure to Co3O4P and CoCl2. Compared with C neg (0 μg mL-1), Co3O4P and CoCl2 induced statistically significant chromosomal damage or loss with micronuclei formation in BN BEAS-2B cells. BNMN induction was significantly higher following exposure to CoCl2 (1.25–2.5–10 μg mL-1 cobalt) than Co3O4P. Mitomycin C (positive clastogenic control; 0.1 μg mL-1) and latex beads LB-3 (50 μg mL-1) also resulted in a significant induction of MN. Data show the number of BNMN cells ± SEM (two independent experiments, 1000 BN in total). Statistical significance versus C neg was evaluated by chi-square test: *p < 0.05; **p < 0.01; ***p < 0.001