Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects

Table 1 Main physicochemical properties of tested AgNPs provided by the manufacturer and reported in the datasheet

		DLS	UV–Vis		TEM
Biopure^TM Silver nanoparticle	Lot N°	Mean hydrodynamic diameter	λmax	Hmax	Diameter	Variation coefficient	Mass concentration	Particle concentration	Solvent	pH of solution
		(nm)	(nm)	(a.u.)	(mean ± SD) (nm)	(%)	(mg/ml)	(n° of particles/ml)
10 nm AgNP-CT	DAG1542	na	388	164.9	8.8 ± 1.7	19.6	1.03	3.5*10¹⁴	2.0 mM citrate	7.3
10 nm AgNP-PVP	DAG1823A	21.3	389	160.2	9.5 ± 1.9	7.5	1.1	2.2*10¹⁴	MilliQ water	6.9
40 nm AgNP-CT	DAG1176	53.7	411	151.1	40.6 ± 3.0	7.0	1.12	2.7*10¹²	2.0 mM citrate	7.6
40 nm AgNP-PVP	DAG1391	49.3	411	148.2	40.7 ± 4.1	20.2	1.1	2.7*10¹²	MilliQ water	6.7
100 nm AgNP-CT	DAG1186	99.8	495	49.2	99.4 ± 7.0	10.0	1.0	1.9*10¹¹	2.0 mM citrate	7.3
100 nm AgNP-PVP	DAG1189	117.0	492	48.2	99.0 ± 5.7	5.8	1.07	1.9*10¹¹	MilliQ water	5.9

CT sodium citrate, PVP polyvinylpyrrolidone, na not available (not reported in the datasheet)

ISSN: 1743-8977