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Table 6 Prevalence of histopathological lesions in mice following IV exposure to 10 mg silver/kg. Data are expressed as number of mice with lesions/total number of examined mice per group (%)

From: Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects

Group

Spleen

Liver

Gall bladder

Lung

Kidney

Brain

Control

1/3 (33 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

10 nm AgNP-CT

3/3 (100 %)

3/3 (100 %)

3/3 (100 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

10 nm AgNP-PVP

3/3 (100 %)

3/3 (100 %)

3/3 (100 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

40 nm AgNP-CT

3/3 (100 %)

1/3 (33 %)

2/3 (67 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

40 nm AgNP-PVP

2/3 (67 %)

0/3 (0 %)

1/3 (33 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

100 nm AgNP-CT

1/3 (33 %)

0/3 (0 %)

2/3 (67 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

100 nm AgNP-PVP

1/3 (33 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

AgAc

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

0/3 (0 %)

3/3 (100 %)

0/3 (0 %)