Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects

Table 7 Grading of most relevant histopathological lesions in mice after IV administration of 10 mg silver/kg. Results are expressed as median score per group (range) (n = 3)

Group	Hepatobiliary tract				Spleen	Kidney
Group	Hepatocellular necrosis and hemorrhage	Peribiliary hemorrhage	Portal vein endothelial damage	Gall bladder hemorrhage	Red pulp hyperemia	Tubular necrosis
Control	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	1 (0–2)	0 (0–0)
10 nm AgNP-CT	4 (3–4)	2 (1–4)	1 (0–4)	2 (2–4)	2 (2–3)	0 (0–0)
10 nm AgNP-PVP	4 (2–4)	2 (1–4)	2 (0–4)	2 (1–4)	3 (3–4)	0 (0–0)
40 nm AgNP-CT	0 (0–1)	0 (0–1)	0 (0–0)	1 (1–4)	2 (2–3)	0 (0–0)
40 nm AgNP-PVP	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–1)	2 (1–2)	0 (0–0)
100 nm AgNP-CT	0 (0–0)	0 (0–0)	0 (0–0)	1 (0–1)	0 (0–1)	0 (0–0)
100 nm AgNP-PVP	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	1 (0–2)	0 (0–0)
AgAc	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	0 (0–0)	4 (3–4)

ISSN: 1743-8977