Fig. 2From: Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubesSchematic of adverse outcome pathway (AOP) for pulmonary injury leading to fibrosis. MIE: molecular initiating event, KE: key event, AO: adverse outcome, AE: associative event, CNT: carbon nanotube, ECM: extracellular matrix. Arrows in inset figure show inflammation at day 1 and fibrosis at day 28 in lung tissueBack to article page