Table 6 Mean opacity and permeability values and corresponding in vitro irritation score (IVIS) of 16 OECD representative nanomaterials (and the Ag NM dispersant) determined in the BCOP assay
Test material | TiO2 NM-100 | TiO2 NM-101 | TiO2 NM-102 | TiO2 NM-103 | TiO2 NM-104 | TiO2 NM-105 | ZnO NM-110 (1st test run) | ZnO NM-110 (2nd test run) | ZnO NM-111 | SiO2 NM-200 | SiO2 NM-203 | CeO2 NM-211 | CeO2 NM-212 | Ag NM-300Â K (1st test run) | Ag NM-300Â K (2nd test run) | Ag dispersant NM-300Â K DIS (1st test run) | Ag dispersant NM-300Â K DIS (2nd test run a) | MWCNT NM-400 | MWCNT NM-401 | MWCNT NM-402 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Volume or mass applied | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 33 mg; undiluted | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; 20 % (w/v) | 750 μL; undiluted | 750 μL; undiluted | 750 μL; undiluted | 750 μL; undiluted | 750 mg; 20 % (w/w) | 48 mg. undiluted | 750 mg; 20 % (w/w) |
Mean opacity value ± SD | 4.2 ± 7.2 | 24.7 ± 4.8 | 10.7 ± 6.1 | 23.8 ± 6.8 | 10.7 ± 4.3 | 2.2 ± 2.8 | 46.6 ± 9.1 | 15.0 ± 3.0 | 1.1 ± 1.1 | 9.7 ± 3.4 | 11.8 ± 3.7 | 18.0 ± 9.9 | 17.2 ± 5.4 | 123.9 ± 80.6 | 2.8 ± 0.6 | 43.9 ± 16.3 | 66.6 ± 2.9 | −4.7 ± 2.2 | −5.4 ± 0.7 | −3.8 ± 0.8 |
Mean permeability value ± SD | −0.01 ± 0.00 | 0.22 ± 0.31 | −0.12 ± 0.01 | 0.14 ± 0.18 | 0.04 ± 0.04 | 0.00 ± 0.00 | 0.20 ± 0.10 | 0.08 ± 0.12 | 0.01 ± 0.03 | 0.02 ± 0.05 | 0.03 ± 0.05 | 0.03 ± 0.04 | −0.02 ± 0.01 | 0.14 ± 0.08 | 3.46 ± 0.46 | 0.08 ± 0.03 | 0.48 ± 0.56 | −0.01 ± 0.00 | 0.01 ± 0.03 | −0.01 ± 0.01 |
IVIS ± SD | 4.1 ± 7.1 | 28.0 ± 4.2 | 10.6 ± 6.2 | 25.9 ± 5.7 | 11.2 ± 4.0 | 2.2 ± 2.8 | 49.5 ± 10.7 | 16.1 ± 4.7 | 1.2 ± 0.7 | 10.0 ± 4.0 | 12.2 ± 2.9 | 18.5 ± 10.5 | 16.9 ± 5.3 | 126.0 ± 81.8 | 54.7 ± 6.3 | 45.0 ± 16.7 | 73.7 ± 11.3 | −4.8 ± 2.3 | −5.3 ± 0.4 | −3.9 ± 0.7 |