Test material | Test run | HSI | Histopathological findings |
---|---|---|---|
TiO2 NM-100 | 1 | 0 | Multifocal brown pigment remnants on squamous surface |
TiO2 NM-101 | 1 | I | Multifocal desquamation and brown granules on the epithelial surface |
TiO2 NM-102 | 1 | 0 | Brown granules on squamous surface |
TiO2 NM-103 | 1 | 0 | No findings |
TiO2 NM-104 | 1 | 0 | No findings |
TiO2 NM-105 | 1 | 0 | No findings |
ZnO NM-110 | 1 | I | Multifocal desquamation |
ZnO NM-110 | 2 | I | Diffuse desquamation |
ZnO NM-111 | 1 | 0 | No findings |
SiO2 NM-200 | 1 | 0 | No findings |
SiO2 NM-203 | 1 | 0 | No findings |
CeO2 NM-211 | 1 | I | Multifocal vacuolation in the squamous and wing cell layers; multifocal desquamation and brown granules on the epithelial surface |
CeO2 NM-212 | 1 | I | Multifocal desquamation and brown granules on the epithelial surface |
Ag NM-300Â K | 1 | IV | All corneas: diffuse cell loss in the squamous and wing layers; two corneas, additionally: multifocal eosinophilic precipitate on the basal lamina; multifocal cell lysis in the basal layer; pyknosis of the upper keratocytes of the stroma |
Ag NM-300Â K | 2 | n.e. | Corneal epithelium completely detached and missing |
Ag dispersant NM-300Â K DIS | 1 | II | Diffuse vacuolation / edema of the squamous and upper wing cell layers; desquamation of the squamous cell layer |
Ag dispersant NM-300Â K DIS | 2 | IV | Multifocal vacuolation of basal layer, epithelial detachment from basal lamina, multifocal eosinophilic precipitate between basal layer and stroma |
MWCNT NM-400 | 1 | 0 | No findings |
MWCNT NM-401 | 1 | 0 | No findings |
MWCNT NM-402 | 1 | 0 | No findings |
aSiO2-susp | 1 | II | Diffuse cell loss |
Quartz dust DQ12 | 1 | 0-I | 1 cornea: no findings; 2 corneas: multifocal desquamation |
Pigment Red 57:1 | 1 | 0 | No findings |
Pigment Yellow 95 | 1 | 0 | No findings |
Pigment Black 32 | 1 | 0 | No findings |
Talc | 1 | 0 | No findings |