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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Meta-analysis of transcriptomic responses as a means to identify pulmonary disease outcomes for engineered nanomaterials

Fig. 3

Enrichment analysis of the biological functions in the Th2 cluster involved the immune response. A short list of genes was generated for the Th2 response cluster (highlighted in blue in Fig. 1). Genes that were differentially expressed in at least 50 % of the arrays that make up the cluster were included in the shortlist. The ClueGO app for Cytoscape software with GO Fusion was utilized to identify biological functions that were enriched in the shortlist and reduce any repetitive GOs. GOs were further collapsed back to their parent GOs to further simplify data presentation. A heatmap was generated to visualize the cluster’s shortlist, organized by biological function

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Particle and Fibre Toxicology

ISSN: 1743-8977

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