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Table 1 Comparison of the levels of inflammatory cytokines and chemokines in the BAL fluid of C57BL/6 female and male mice 3 months after repeated exposure with CNC

From: Gender differences in murine pulmonary responses elicited by cellulose nanocrystals

Cytokines Control (pg/ml) Females (fold of control) Males (fold of control)
IL-1α 1.11 ± 0.05 1.78 ± 0.08* 1.87 ± 0.10*
IL-1β 24.75 ± 0.70 2.21 ± 0.12*# 1.68 ± 0.08*
IL-2 1.95 ± 0.11 1.73 ± 0.12* 1.69 ± 0.19*
IL-4 2.68 ± 0.03 1.34 ± 0.04* 1.29 ± 0.02*
IL-5 1.77 ± 0.10 1.87 ± 0.11*# 0.85 ± 0.09
IL-6 3.92 ± 0.17 1.29 ± 0.08* 1.08 ± 0.05
IL-10 6.83 ± 0.27 1.53 ± 0.08*# 1.28 ± 0.12*
IL-12(p40) 110.30 ± 7.11α 3.80 ± 0.26* 3.20 ± 0.27*
66.76 ± 1.99β
IL-12(p70) 24.95 ± 0.80 1.36 ± 0.07*# 1.17 ± 0.04
IL-13 113.39 ± 3.09 1.27 ± 0.04* 1.16 ± 0.05
IL-17A 4.20 ± 0.20 1.51 ± 0.06*# 0.99 ± 0.08
Eotaxin 468.96 ± 32.56 1.15 ± 0.07 1.32 ± 0.07*
G-CSF 6.77 ± 0.19 1.32 ± 0.05* 1.18 ± 0.08*
KC 7.73 ± 0.21 4.16 ± 0.56*# 2.33 ± 0.18*
MCP-1 29.30 ± 0.72 8.15 ± 1.7*# 2.35 ± 0.26*
MIP-1α 5.81 ± 0.16 13.43 ± 1.63*# 6.51 ± 0.64*
MIP-1β 3.50 ± 0.18 2.17 ± 0.12*# 1.42 ± 0.09*
RANTES 2.37 ± 0.22 1.87 ± 0.15* 1.90 ± 0.28*
  1. The control values otherwise noted correspond to the mean absolute values (pg/ml) from PBS-exposed male mice. The PBS-exposed control female and male mice were not significantly different, except for IL-12(p40). Level of IL-12(p40) for control femalesα mice (110.30 ± 7.11 pg/ml) was significantly different as compared to control malesβ mice (66.76 ± 1.99 pg/ml). For comparison, cytokines data presented as folds of control for female and male mice exposed to CNC. Mean ± SEM (n = 10 mice/group). *p < 0.05, vs control PBS-exposed mice, # p < 0.05, vs male mice exposed to CNC