Gender differences in murine pulmonary responses elicited by cellulose nanocrystals

Table 1 Comparison of the levels of inflammatory cytokines and chemokines in the BAL fluid of C57BL/6 female and male mice 3 months after repeated exposure with CNC

Cytokines	Control (pg/ml)	Females (fold of control)	Males (fold of control)
IL-1α	1.11 ± 0.05	1.78 ± 0.08^*	1.87 ± 0.10^*
IL-1β	24.75 ± 0.70	2.21 ± 0.12^*#	1.68 ± 0.08^*
IL-2	1.95 ± 0.11	1.73 ± 0.12^*	1.69 ± 0.19^*
IL-4	2.68 ± 0.03	1.34 ± 0.04^*	1.29 ± 0.02^*
IL-5	1.77 ± 0.10	1.87 ± 0.11^*#	0.85 ± 0.09
IL-6	3.92 ± 0.17	1.29 ± 0.08^*	1.08 ± 0.05
IL-10	6.83 ± 0.27	1.53 ± 0.08^*#	1.28 ± 0.12^*
IL-12(p40)	110.30 ± 7.11^α	3.80 ± 0.26^*	3.20 ± 0.27^*
IL-12(p40)	66.76 ± 1.99^β	3.80 ± 0.26^*	3.20 ± 0.27^*
IL-12(p70)	24.95 ± 0.80	1.36 ± 0.07^*#	1.17 ± 0.04
IL-13	113.39 ± 3.09	1.27 ± 0.04^*	1.16 ± 0.05
IL-17A	4.20 ± 0.20	1.51 ± 0.06^*#	0.99 ± 0.08
Eotaxin	468.96 ± 32.56	1.15 ± 0.07	1.32 ± 0.07^*
G-CSF	6.77 ± 0.19	1.32 ± 0.05^*	1.18 ± 0.08^*
KC	7.73 ± 0.21	4.16 ± 0.56^*#	2.33 ± 0.18^*
MCP-1	29.30 ± 0.72	8.15 ± 1.7^*#	2.35 ± 0.26^*
MIP-1α	5.81 ± 0.16	13.43 ± 1.63^*#	6.51 ± 0.64^*
MIP-1β	3.50 ± 0.18	2.17 ± 0.12^*#	1.42 ± 0.09^*
RANTES	2.37 ± 0.22	1.87 ± 0.15^*	1.90 ± 0.28^*

The control values otherwise noted correspond to the mean absolute values (pg/ml) from PBS-exposed male mice. The PBS-exposed control female and male mice were not significantly different, except for IL-12(p40). Level of IL-12(p40) for control females^α mice (110.30 ± 7.11 pg/ml) was significantly different as compared to control males^β mice (66.76 ± 1.99 pg/ml). For comparison, cytokines data presented as folds of control for female and male mice exposed to CNC. Mean ± SEM (n = 10 mice/group). *p < 0.05, vs control PBS-exposed mice, ^# p < 0.05, vs male mice exposed to CNC

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