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Table 2 BALF protein analysis at 1 day, 7 days and 1 month

From: Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family

  1 Day 7 Day 1 Month
Protein Gr20 - High Gr5 - High Gr1 - High CB - High Gr20 - High Gr5 - High Gr1 - High CB - High Gr20 - High Gr5 - High Gr1 - High CB - High
Apo A-1 3.44 b,c 3.02 b,c 1.54 2.57 b 0.98 0.76 0.73 0.48 1.26 1.34 1.24 0.94
CRP Mouse 1.94 c 1.53 c 1.18 1.29 1.07 1.07 0.80 1.00 1.29 1.21 1.29 1.07
CD40 BLD BLD BLD 1.36 e BLD 1.63 BLD 1.69 BLD BLD BLD BLD
CD40L 26.74 c 35.13 c 9.3 b 33.74 c 2.41 2.76 0.97 3.04 1.00 1.13 0.62 0.78
Eotaxin 3.2 c 6.46 c 1.36 b 2.04 c 1.46 1.56 1.22 1.22 1.07 1.08 1.10 0.94
EGF Mouse 2.63 b,c 3.12 c 2.34 b 3.12 c 2.46 a 2.28 a 2.06 a 2.02 a 0.84 0.94 0.68 0.68
Factor VII 1.83 b 2.53 c 1.66 b 2.23 c 1.73 1.41 1.47 1.39 1.08 1.11 1.07 0.98
Fibrinogen 2.77 c 2.35 c 1.26 2.07 c 1.29 0.94 0.79 1.12 1.35 a 1.28 1.23 1.11
GCP-2 Mouse 1.83 b 2.70 c 2.94 c 3.17 c 2.12 c 1.71 c 2.27 c 1.68 1.04 0.89 0.70 0.97
GM-CSF 2.39 b 5.75 c 4.49 c 24.48 e 2.02 1.36 1.71 1.18 1.15 1.06 0.87 0.92
KC/GRO 4.17 b 12.5 c 7.08 c 23.33 e BLD BLD BLD BLD BLD BLD BLD BLD
IgA 0.93 1.64 1.00 1.30 0.86 0.84 0.80 0.65 1.18 1.00 0.99 1.03
IP-10 10.76 b 14.28 b 1.98 7.59 b 1.48 1.58 1.48 2.47 0.84 1.02 0.93 1.02
IL-1α 1.86 b 2.66 c 1.78 b 3.32 c 2.45 3.46 2.62 2.57 1.26 1.55 0.42 1.31
IL-1β 1.26 2.00 1.01 2.08 c 0.99 1.03 0.82 0.87 0.72 1.22 1.32 1.12
IL-5 6.22 d 8.49 d 1.26 2.26 c BLD BLD BLD BLD BLD BLD BLD BLD
IL-6 16.34 c 39.02 e 4.65 b 13.99 c BLD BLD BLD BLD BLD BLD BLD BLD
IL-18 1.60 b 2.26 c 1.50 b 2.74 c 0.99 1.35 0.96 1.10 0.81 1.17 0.92 1.06
LIF 3.91 c 6.57 d 1.99 b 3.01 c 2.2 5 a 1.81 1.89 1.62 1.00 0.98 0.81 0.87
Lymphotactin 1.61 2.39 c 1.14 1.91 1.18 1.10 1.17 1.42 0.62 0.81 1.00 1.01
 M-CSF-1 1.62 b 2.31 c 1.62 b 3.91 e 1.32 1.22 1.03 1.19 1.18 c 1.27 c 0.97 0.92
 MDC 6.04 c 8.58 e 1.78 4.09 c 2.34 a 1.84 a 1.51 a 1.78 a 1.63 c 1.76 c 1.10 1.36
 MIP-1α 2.84 c 4.12 d 1.70 b 3.56 d 2.50 2.32 2.40 1.71 1.82 3.33 b 1.81 1.50
 MIP-1β 14.51 c 14.99 c 3.09 b 12.94 c 1.40 1.79 1.46 2.13 0.82 1.25 0.75 0.74
 MIP-1γ 6.33 c 9.03 c 3.94 b 10.35 c 2.95 a 3.78 a 1.38 2.11 2.75 c 3.69 c 1.30 1.69
 MIP-2 4.54 c 5.54 c 2.94 b 5.70 c 2.26 a 1.93 1.89 1.76 0.76 0.96 0.60 0.85
 MIP-3 2.34 c 3.56 e 1.78 b 2.50 c 2.13 a 2.08 a 2.15 a 1.95 a 1.17 1.09 0.88 1.01
 MMP-9 71.42 c 52.44 c 11.19 b 46.72 c 4.08 4.51 2.46 4.90 2.07 c 1.87 c 0.63 0.95
 MCP-1 17.86 c 25.76 c 0.98 15.54 c BLD BLD BLD 7.06 BLD BLD BLD BLD
 MCP-3 38.32 c 42.07 c 3.01 b 21.82 c 1.18 3.57 a 1.65 a 5.56 a 1.13 2.04 e 0.97 1.05
 MCP-5 9.27 c 10.11 c BLD 5.38 c BLD BLD 0.73 1.03 BLD BLD BLD BLD
 MPO 51.27 c 66.02 d 18.32 c 62.77 d 21.78 a 20.26 c 7.23 a 25.24 c 4.68 c 3.58 c 0.59 1.01
 PAI-1 1.84 c 2.63 e 1.50 b 1.64 c 1.17 1.11 0.98 1.21 1.12 1.37 1.15 1.14
 SAP 2.63 b,c 2.03 b 1.09 1.50 1.38 1.00 0.68 0.71 1.00 0.97 1.13 0.63
 SCF 2.36 b 3.37 c 1.39 2.66 c 0.88 1.43 1.51 2.09 1.26 0.88 0.82 0.83
Thrombopoetin 2.53 b 4.17 c 2.20 b 4.42 c 1.47 1.03 BLD BLD BLD 1.58 BLD BLD
 TIMP-1 17.32 d 18.88 d 2.95 b 7.49 c 1.59 1.82 a 1.12 1.18 1.37 1.53 c 1.30 1.97
 TNF-α BLD 3.90 e BLD BLD BLD BLD BLD BLD BLD BLD BLD BLD
 VCAM-1 1.88 c 2.08 c 1.30 1.86 c 1.13 1.21 0.84 1.07 1.16 1.20 1.08 0.98
 VEGF-A 2.16 c 2.45 c 1.44 b 2.49 c 1.14 1.08 1.04 1.04 0.96 0.98 0.93 0.85
 vWF 1.76 b 2.10 b 1.73 b 2.33 c 1.63 1.63 1.52 1.29 1.22 1.11 1.00 1.05
  1. Data in the table represent fold-increase for proteins that were significantly different for one or more groups at one or more time points post-exposure based on RodentMap® v2.0. The low dose groups were tested only at 1 day post-exposure. BLD – below the limit of detection. Groups with like symbols denote statistically similar group; astatistically different from DM only; bstatistically different from DM and all low dose groups; cstatistically different from DM and at least one high dose group; dstatistically different from statistically different from DM, low dose groups, and at least one high dose group; estatistically different from all groups; p < 0.05. Bold text without symbols denotes significance at p < 0.07