Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits

Table 4 Fetal metabolism at 28 dpc for the second generation

Variable	Number of fetuses		Median [Q1; Q3]		Fully adjusted linear model
Variable	C	E	C	E	β value	CI	P-value
Glycemia (mmol/L)	14	12	1.400 [1.175; 1.765]	1.730 [1.618; 2.070]	0.257	[−0.173;0.687]	0.275
Insulin (mUI/L)	14	12	4.170 [1.990; 10.09]	2.545 [1.703; 3.765]	−2.965	[−6.245;0.315]	0.111
Total cholesterol (mmol/L)	15	12	2.550 [2.180; 2.640]	1.890 [1.800; 2.240]	−0.416	[−0.648;-0.183]	0.008**
HDL cholesterol (mmol/L)	15	12	0.730 [0.685; 0.790]	0.650 [0.590; 0.750]	−0.071	[−0.156;0.015]	0.143
Non-HDL cholesterol (mmol/L)	15	12	1.730 [1.480; 1.898]	1.280 [1.150; 1.480]	−0.348	[−0.54;-0.156]	0.007**
Triglycerids (mmol/L)	15	12	0.540 [0.440; 0.598]	0.680 [0.610; 0.730]	0.176	[0.062;0.289]	0.015*
ASAT (UI/L)	15	10	107.5 [97.00; 116.0]	110.0 [95.00; 137.0]	15.66	[−14.542;45.863]	0.335
Creatinine (μmol/L)	15	12	72.00 [66.00; 76.25]	72.00 [67.00; 77.00]	0.082	[−6.745;6.909]	0.982
Urea (mmol/L)	15	12	4.650 [3.950; 5.200]	3.700 [3.500; 4.600]	−0.303	[−1.779;1.174]	0.696

The effects of exposure to engine diesel exhaust during grand-mother pregnancy on second-generation fetuses were estimated using a linear model with random effect of dam adjusted for litter size, fetal sex and the position of the fetus in the horn. All data are expressed as median [Q1;Q3] (*p < 0.05, **p < 0.01, compared with control group)

ISSN: 1743-8977