| Group ID | Sunscreen | UVR kJ/m2 | Number of mice per group | Number of mice that reached endpoint without AE | Total mice with AE | Mice with AE related to malignant or pre-malignant findings (histologically diagnosed) | Mice with AE related to non-malignant findings (histologically diagnosed) | Mice with AE, no necroscopy | Total mice at predetermined endpoint with malignant findings (histologically diagnosed) | Total mice at predetermined endpoint with non-malignant findings (histologically diagnosed) | Total mice at predetermined endpoint with no malignant or non-malignant findings |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Series 1 | Control-UVR | None | 0 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 10 |
Control + UVR | None | 29 | 10 | 6 | 4 | 4 (1 X CFS; 1 X CFS + SCC; 1 X LL; 1 X SCP) | 0 | 0 | 1 (1 X SCP) | 4a | 1 | |
ZnO-UVR | ZnO | 0 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 1 (1 X PA) | 9 | |
ZnO + UVR | ZnO | 29 | 10 | 5 | 5 | 1 (1 X LL) | 2 (1 X N; 1 X HC) | 2 | 1 (1 X CFS) | 0 | 4 | |
TiO2-UVR | TiO2 | 0 | 10 | 9 | 1 | 0 | 1 (1 X P) | 0 | 0 | 0 | 9 | |
TiO2 + UVR | TiO2 | 29 | 10 | 10 | 0 | 0 | 0 | 0 | 2 (2 X BAC) | 1 (1 X PA) | 7 | |
Organic-UVR | Organic | 0 | 10 | 9 | 1 | 1 (1 X LL) | 0 | 0 | 0 | 0 | 9 | |
Organic + UVR | Organic | 29 | 10 | 9 | 1 | 0 | 0 | 1 | 1 (1 X LL) | 0 | 8 | |
Series 2 | 2-Control-UVR | None | 0 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 10 |
2-Control + UVR | None | 27 | 10 | 9 | 1 | 1 (1 X LL) | 0 | 0 | 7 (1 X BAC; 4 X SCC; 1 X LL; 1 X CFS & SCP) | 0 | 2 | |
2-ZnO-UVR | ZnO | 0 | 10 | 9 | 1 | 1 (1 X LL) | 0 | 0 | 1 (1 X OS) | 0 | 8 | |
2-ZnO + UVR | ZnO | 27 | 10 | 9 | 1 | 0 | 1 (1 X E) | 0 | 0 | 0 | 9 |