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Table 4 Calculated pharmacological values for aortic ring constrictor and relaxation response

From: Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury

Treatment Group

EC50 (nM)

Hill slope

PE

ACh

SNP

PE

ACh

SNP

 Naive

565.9 ± 129.8

127.4 ± 19.4

104.1 ± 25.3

1.7 ± 0.2

1.8 ± 0.3

2.1 ± 0.4

1 Day Post IT Exposure

 Citrate

501.9 ± 125.4

108.8 ± 47.0

74.3 ± 29.5

1.8 ± 0.2

1.4 ± 0.3

1.8 ± 0.2

 20 nm AgNP

311.4 ± 58.1

97.79 ± 17.9

28.6 ± 8.0

1.7 ± 0.1

1.5 ± 0.1

1.8 ± 0.2

 110 nm AgNP

558.5 ± 122.2

58.45 ± 18.1

20.9 ± 4.2

1.7 ± 0.2

1.8 ± 0.5

1.8 ± 0.3

 PVP

450.2 ± 60.3

101.9 ± 20.7

44.8 ± 4.8a

1.5 ± 0.0

1.7 ± 0.1

1.7 ± 0.1

 20 nm AgNP

593.0 ± 161.8

121.6 ± 31.9

40.5 ± 10.6a

1.9 ± 0.4

1.6 ± 0.1

1.8 ± 0.2

 110 nm AgNP

490.8 ± 156.2

119.3 ± 20.1

20.9 ± 4.2a

1.7 ± 0.2

1.7 ± 0.4

1.9 ± 0.4

7 Day Post IT Exposure

 Citrate

497.6 ± 11.8

106.1 ± 57.9

26.4 ± 6.6a

1.8 ± 0.2

1.8 ± 0.2

1.7 ± 0.2

 20 nm AgNP

256.2 ± 58.0

63.4 ± 7.4

45.1 ± 1.0a

1.6 ± 0.1

1.6 ± 0.1

1.6 ± 0.2

 110 nm AgNP

540.4 ± 18.0

84.2 ± 26.3

66.3 ± 29.3

1.6 ± 0.1

1.6 ± 0.1

1.8 ± 0.1

 PVP

215.0 ± 15.0

196.6 ± 82.2

40.1 ± 18.8

1.1 ± 0.1

1.5 ± 0.4

1.7 ± 0.4

 20 nm AgNP

122.9 ± 14.1a

120.0 ± 13.2

66.6 ± 14.9

1.1 ± 0.1

1.1 ± 0.2

1.5 ± 0.2

 110 nm AgNP

260.3 ± 50.0

66.2 ± 17.7

66.4 ± 10.6

1.1 ± 0.0

2.0 ± 0.3

1.5 ± 0.4

  1. The calculated mean EC50, and Hill slope, responses of aorta segment to phenylephrine (PE), acetylcholine (ACh), and sodium nitroprusside (SNP) 1 day and 7 days post 200 μl instillation of Citrate or PVP vehicle or 200 μg 20 or 110 nm AgNP. Values expressed mean ± SEM. adenotes significant versus Naïve (p < 0.05) calculated by one-way ANOVA with Tukey Post Hoc test, n = 3–8