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Table 4 Calculated pharmacological values for aortic ring constrictor and relaxation response

From: Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury

Treatment Group EC50 (nM) Hill slope
PE ACh SNP PE ACh SNP
 Naive 565.9 ± 129.8 127.4 ± 19.4 104.1 ± 25.3 1.7 ± 0.2 1.8 ± 0.3 2.1 ± 0.4
1 Day Post IT Exposure
 Citrate 501.9 ± 125.4 108.8 ± 47.0 74.3 ± 29.5 1.8 ± 0.2 1.4 ± 0.3 1.8 ± 0.2
 20 nm AgNP 311.4 ± 58.1 97.79 ± 17.9 28.6 ± 8.0 1.7 ± 0.1 1.5 ± 0.1 1.8 ± 0.2
 110 nm AgNP 558.5 ± 122.2 58.45 ± 18.1 20.9 ± 4.2 1.7 ± 0.2 1.8 ± 0.5 1.8 ± 0.3
 PVP 450.2 ± 60.3 101.9 ± 20.7 44.8 ± 4.8a 1.5 ± 0.0 1.7 ± 0.1 1.7 ± 0.1
 20 nm AgNP 593.0 ± 161.8 121.6 ± 31.9 40.5 ± 10.6a 1.9 ± 0.4 1.6 ± 0.1 1.8 ± 0.2
 110 nm AgNP 490.8 ± 156.2 119.3 ± 20.1 20.9 ± 4.2a 1.7 ± 0.2 1.7 ± 0.4 1.9 ± 0.4
7 Day Post IT Exposure
 Citrate 497.6 ± 11.8 106.1 ± 57.9 26.4 ± 6.6a 1.8 ± 0.2 1.8 ± 0.2 1.7 ± 0.2
 20 nm AgNP 256.2 ± 58.0 63.4 ± 7.4 45.1 ± 1.0a 1.6 ± 0.1 1.6 ± 0.1 1.6 ± 0.2
 110 nm AgNP 540.4 ± 18.0 84.2 ± 26.3 66.3 ± 29.3 1.6 ± 0.1 1.6 ± 0.1 1.8 ± 0.1
 PVP 215.0 ± 15.0 196.6 ± 82.2 40.1 ± 18.8 1.1 ± 0.1 1.5 ± 0.4 1.7 ± 0.4
 20 nm AgNP 122.9 ± 14.1a 120.0 ± 13.2 66.6 ± 14.9 1.1 ± 0.1 1.1 ± 0.2 1.5 ± 0.2
 110 nm AgNP 260.3 ± 50.0 66.2 ± 17.7 66.4 ± 10.6 1.1 ± 0.0 2.0 ± 0.3 1.5 ± 0.4
  1. The calculated mean EC50, and Hill slope, responses of aorta segment to phenylephrine (PE), acetylcholine (ACh), and sodium nitroprusside (SNP) 1 day and 7 days post 200 μl instillation of Citrate or PVP vehicle or 200 μg 20 or 110 nm AgNP. Values expressed mean ± SEM. adenotes significant versus Naïve (p < 0.05) calculated by one-way ANOVA with Tukey Post Hoc test, n = 3–8