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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes

Fig. 8

Cytokine expression profile in the C57BL/6 hippocampus after acute (1-day) exposure to atmospheres. After 1-day of exposure to atmospheres, cytokine mRNA expression was assessed in the hippocampus of the C57BL/6 mouse brain for the following: (a) Ccl5, (b) Cxcl1, (c) IL-1β, (d) IL-6, (e) Tgf-β, and (f) Tnf-α. Exposure to UFP significantly altered mRNA expression of (a) Ccl5, (b) Cxcl1, (c) IL-1β, (e) Tgf-β, and (f) Tnf-α. Exposure to UFP+G or FP+G significantly increased mRNA expression of (c) IL-1β. Exposure to UFP + G, FP and FP + G significantly decreased mRNA expression of (d) IL-6 and (e) Tgf-β. n = 7–8 per group, *p < .05; **p < .01; ***p < .001; ****p < .0001

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