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Table 2 Experimental design

From: Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles

Nominal particle diameter (nm) Exposure duration (mins) Total animals Post-exposure sacrifice time (group size)
Main study – Clearance and translocation
10* 120 36 0 h (6), 24 h (4), 3d (4), 7d (4), 14d (4), 30d (5), 63d (4), 90d (5)
15 75 35 0 h (10), 24 h (5), 2d (4), 5d (4), 9d (4), 28d (4), 109d (4)
35 180 36 0 h (6), 24 h (6), 3d (4), 7d (4), 14d (4), 28d (4), 64d (4), 589d (4)
75 60 9 0 h (5), 30d (4)
Supplementary study A – Clearance
15 10 5  
15 20 5  
15 40 5  
15 60 5  
Supplementary study B – Additional samples for imaging
10 120 6 24 h (2), 5d (2), 30d (2)
75 60 6 24 h (2), 5d (2), 30d (2)
  1. *For the 10 nm study additional animals (system controls) were exposed in the same system to gases without nanoparticles for 120 mins and sacrificed at 3 and 7 days post-exposure