Table 2 Experimental design
From: Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles
Nominal particle diameter (nm) | Exposure duration (mins) | Total animals | Post-exposure sacrifice time (group size) |
|---|---|---|---|
Main study – Clearance and translocation | |||
10* | 120 | 36 | 0 h (6), 24 h (4), 3d (4), 7d (4), 14d (4), 30d (5), 63d (4), 90d (5) |
15 | 75 | 35 | 0 h (10), 24 h (5), 2d (4), 5d (4), 9d (4), 28d (4), 109d (4) |
35 | 180 | 36 | 0 h (6), 24 h (6), 3d (4), 7d (4), 14d (4), 28d (4), 64d (4), 589d (4) |
75 | 60 | 9 | 0 h (5), 30d (4) |
Supplementary study A – Clearance | |||
15 | 10 | 5 | |
15 | 20 | 5 | |
15 | 40 | 5 | |
15 | 60 | 5 | |
Supplementary study B – Additional samples for imaging | |||
10 | 120 | 6 | 24 h (2), 5d (2), 30d (2) |
75 | 60 | 6 | 24 h (2), 5d (2), 30d (2) |