Particle and Fibre Toxicology

Table 1 Hematological analysis of blood samples for platelet parameters following inhalation (4 h and 24 h) and intra-arterial infusion (4 h) of carbon nanoparticle (CNP) in mice compared to control

From: Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

Platelet Parameters	Inhalation						Intra-arterial Infusion
	4 h			24 h			4 h
	Control	CNP	p	Control	CNP	p	Control	CNP	p
PLT (×10E3 CELLS/μL)	809.50 ± 86.95	1203.13 ± 54.84	*↑	868.50 ± 96.65	1103.57 ± 17.77	*↑	902.50 ± 62.56	909.67 ± 69.40	NS
Large PLT (×10E3 CELLS/μL)	1.88 ± 0.40	17.63 ± 2.71	*↑	4.25 ± 1.32	9.00 ± 1.34	*↑	22.33 ± 4,72	25.50 ± 5.60	NS
MPV (fl)	5.45 ± 0.15	7.66 ± 0.16	*↑	5.99 ± 0.29	7.04 ± 0.10	*↑	7.97 ± 0.30	8.28 ± 0.58	NS
PCT (%)	0.45 ± 0.06	0.92 ± 0.04	*↑	0.53 ± 0.08	0.78 ± 0.02	*↑	0.73 ± 0.07	0.74 ± 0.06	NS
PDW (%)	51.65 ± 1.15	58.70 ± 0.79	*↑	53.63 ± 2.37	56.99 ± 1.02	NS	68.83 ± 2.52	65.25 ± 1.70	NS
MPC (g/dl)	24.93 ± 0.42	19.86 ± 0.32	*↓	23.53 ± 0.72	21.29 ± 0.21	*↓	19.90 ± 0.58	19.58 ± 1.12	NS
PCDW (g/dl)	7.41 ± 0.17	8.10 ± 0.08	*↑	7.61 ± 0.24	8.21 ± 0.06	*↑	7.95 ± 0.10	7.93 ± 0.11	NS
MPM (pg)	1.23 ± 0.01	1.26 ± 0.01	*↑	1.24 ± 0.01	1.27 ± 0.01	*↑	1.31 ± 0.01	1.31 ± 0.01	NS
PMDW (pg)	0.43 ± 0.01	0.42 ± 0.01	NS	0.43 ± 0.01	0.43 ± 0.01	NS	0.49 ± 0.01	0.48 ± 0.01	NS

PLT platelet, Large PLT large platelet count, MPV mean platelet volume, PCT plateletcrit, PDW platelet distribution width, MPC mean platelet component, PCDW Platelet component distribution width, MPM mean platelet mass, PMDW platelet mass distribution width. Data is shown as Mean ± SEM; inhalation: n = 8; infusion: n = 6; * p < 0.05; ↑: significantly increased; ↓: significantly decreased; NS not significant

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ISSN: 1743-8977

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