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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats

Fig. 9

Effects of nanoparticle exposure on immunohistochemistry marker levels in lung tissue. The level of a γ-H2AX for genotoxicity, b 8-OHdG for oxidative stress, and Ki67 for cell proliferation in c terminal bronchi and d lung parenchym were determined immunohistochemically in lung tissue of rats exposed to clean air, 3.0 mg/m3 CeO2 or 50.0 mg/m3 BaSO4 for one, 28 and 90 days as well as after 28 and 90 post-exposure days. Values are expressed as percentage of positive cells per total cell number or number of positive cells per μm length of terminal bronchus, mean ± SD, * p < 0.05, ** p < 0.01 vs. clean air control, n = 6; Kruskal-Wallis-ANOVA with Mann-Whitney U-Test as post-hoc analysis

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