Fig. 4
BACE1 inhibition maintains functional synaptic integrity following PM2.5 aspiration. (a1) Representative protein bands of immunoblot analysis for BACE1 and red fluorescent protein (RFP). (a2) Quantification of BACE1 and RFP expression. (b1) Representative protein bands of immunoblot analysis for AMPA (GluA1 and GLuA2), NMDA (GluN1, GRIN2A, and GRIN2B) and RFP. (b2) Quantification of AMPA (GluA1 and GluA2), NMDA (GluN1, GRIN2A, and GRIN2B) and RFP expression. (c1) Representative protein bands of immunoblot analysis for PSD-95 and RFP expression. (c2) Quantifications of PSD-95 and RFP expression. RFP expression was used as a marker to indicate viral infection in the immunoblot assay. The data are expressed as the means ± SE (n = 6 to 8 mice/group). (d1) Time courses of changes in the field excitatory postsynaptic potential (fEPSP) slope under different treatments. (d2) Mean values of the fEPSP slope averaged from 56 to 60 min after theta burst stimulation (TBS). The data are expressed as the means ± SE (n = 6 mice/group). */# P < 0.05; **/## P < 0.01; ***/### P < 0.001