Fig. 7

STAT6 deficiency suppresses fibrotic genes 24 h and 28 days post MWCNT exposure. RNA was isolated from the lung tissue of MWCNT-administered mice 24 h and 28 days post-exposure. a The number of differentially expressed genes (DEGs) is visualized by a bar chart and the number of significant (at least a 1.5 fold change and an FDR adjusted p < 0.05) DEGs between WT and STAT6 KO mice is indicated for both time points. b Venn analysis was used to visualize the degree of overlap between increasing and decreasing DEGs at the 24 h and 28 day time points. c A heat map visualizing all of the DEGs involved in inflammation and fibrosis is shown. The genes are ordered based on the difference in expression between WT and STAT6 KO mice