Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice

Table 3 Summary of gpt mutations in the lungs of control and metal nanoparticle-exposed mice

Type of mutation in gpt	Control		Nano-Co		Nano-TiO₂
Type of mutation in gpt	No.	%	No.	%	No.	%
Transition
G:C to A:T	6	31.6	14	22.6	13	34.2
A:T to G:C	2	10.5	1	1.6	6	15.8
Transversion
G:C to T:A	6	31.6	38	61.3	11	28.9
G:C to C:G	0	0	1	1.6	0	0
A:T to T:A	0	0	1	1.6	0	0
A:T to C:G	2	10.5	2	3.2	3	7.9
Deletions	1	5.3	1	1.6	1	2.6
Insertions	2	10.5	2	3.2	3	7.9
Others	0	0	2	3.2	0	0
Total	19	100	62	100	38	100

Mice were instilled intratracheally with 50 μg per mouse of Nano-Co or Nano-TiO₂. Control mice were instilled with physiological saline. Lung tissues were collected four months after exposure

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