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Table 6 Pulmonary clearance rate constants and initial fraction of administered NiO that reached the alveolar region

From: Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats

  Dose Clearance rate constants k Lung (1/day) Half time t 1/2 (day) Initial fraction reaching the alveolar region r Translocation rate constants k Lung  → Lym (1/day)
NiO A 0.57 mg/kg-bw 0.0022 310 day 57% 0.00014
1.9 mg/kg-bw 0.000 >690 day 58% 0.00048
5.8 mg/kg-bw 0.0017 410 day 68% 0.00076
NiO B 0.45 mg/kg-bw 0.15 4.5 day 54% 0.000024
1.5 mg/kg-bw 0.16 4.4 day 38% 0.000024
4.0 mg/kg-bw 0.15 4.5 day 36% 0.000039
NiO C 0.47 mg/kg-bw 0.012 59 day 5.0% 0.000031
2.0 mg/kg-bw 0.0041 170 day 20% 0.00017
5.8 mg/kg-bw 0.000 >690 day 42% 0.00050
NiO D 0.50 mg/kg-bw 0.0073 96 day 97% 0.00045
1.6 mg/kg-bw 0.0061 110 day 94% 0.00078
5.0 mg/kg-bw 0.0084 82 day 88% 0.0014
  1. Data estimated from the lung and bronchoalveolar lavage fluid (BALF) burden data, using a one-compartment model