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Fig. 1 | Particle and Fibre Toxicology

Fig. 1

From: On the pivotal role of dose for particle toxicology and risk assessment: exposure is a poor surrogate for delivered dose

Fig. 1

Normalized delivered dose (dose per surface area or mass of lung/tissue) and not exposure plays the pivotal role for derivation of human exposure limits from toxicological inhalation studies. The main factors influencing conversion of PSP aerosol exposure concentration into (lung-) delivered dose are depicted for animal inhalation experiments and factors relevant for extrapolation of No or Low Observed Adverse Effect Levels (NOAEL/LOAEL) from animal models to humans are highlighted

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Particle and Fibre Toxicology

ISSN: 1743-8977

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