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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs

Fig. 4

Immunostaining of lung samples following 6 weeks exposure to PbO-NPs. a-c PCNA in lung tissue. Arrows indicate PCNA-positive cells in lung. The highest amount of positive cells is in infiltrates. d-f TUNEL in lung tissue. Arrows indicate TUNEL-positive cells, mainly macrophages and some immune cells in infiltrates. g-i Na-K ATPase in control samples. Cells with high positivity are macrophages and bronchiolar epithelial cells. j-l Na-K ATPase in treated samples without outstanding changes. Arrows indicate positive macrophages. Scale bar in all panels = 100 μm

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