Table 4 DNA strand break levels (% tail DNA) in lung tissue 1, 28 and 180 days following intratracheal instillation and from the BAL cells 1 and 28 days following intratracheal instillation of 162 μg of TiO2, CeO2 or CB determined by the Comet assay
From: Primary genotoxicity in the liver following pulmonary exposure to carbon black nanoparticles in mice
DNA SB in the lungs following intratracheal instillation | ||||
| Â | Control | TiO2 | CeO2 | CB |
day 1 | 3.3 ± 0.8 | 3.2 ± 0.9 | 3.8 ± 0.6 | 4.6 ± 1.0 |
day 28 | 6.1 ± 1.3 | 5.9 ± 0.9 | 5.5 ± 1.1 | 5.3 ± 1.2 |
day 180 | 3.6 ± 1.0 | 5.2 ± 0.9* | 4.2 ± 1.1 | 5.1 ± 1.4 |
DNA SB in the BAL cells following intratracheal instillation | ||||
| Â | Control | TiO2 | CeO2 | CB |
day 1 | 4.5 ± 0.7 | 4.4 ± 0.9 | 5.6 ± 1.3 | 5.8 ± 1.2 |
day 28 | 5.9 ± 1.1 | 4.0 ± 1.0 | 4.3 ± 1.0 | 4.0 ± 1.4 |