Fig. 5
From: Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome
Assessment of disease and signaling pathways altered epigenetically during maternal nano-TiO2 exposure. a One of the primary disease pathways (z-score = 9.35 ± 1.89) altered epigenetically during exposure was the increased susceptibility to infection in the H3K4me3 group. Disease and toxicological pathways are constructed from specific, individual canonical signaling pathways. b Depicts the top canonical pathways for H3K4me3 (z-score ≥ ±2.0) that are significantly (P ≤ 0.05) impacted, as indicated by the threshold line. c The top canonical pathways for H3K27me3 (P ≤ 0.05) are also shown following exposure (smaller p-values are associated with increasing red intensity for pathways). d Toxicological functions predicted for genes mapped to H3K4me3 marks