Fig. 1From: ISD3: a particokinetic model for predicting the combined effects of particle sedimentation, diffusion and dissolution on cellular dosimetry for in vitro systemsProcesses represented in ISD3. Particles of different sizes settle and diffuse at different rates. Dissolution of particles reduces the size of particles and increases the concentration of ions in the liquid column. Dissolution and cellular uptake of particles reduce the number of particles for each particle size class. Ions are uniformly distributed in the liquid column, and their concentration increases due to dissolution and decreases due to cell uptakeBack to article page