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Table 4 Log EC50 and Emax values of concentration-response curves in aorta and left anterior descending coronary artery (LAD)

From: Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

  Dose (mg/kg bw/week) Log EC50 (M) Emax (%)
Aorta LAD proximal LAD distal Aorta LAD proximal LAD distal
ACh
Control 0 −5.8 (−6.1 to −5.4) −7.3 (−7.4 to − 7.2) −7.5 (− 7.7 to − 7.3) 38.9 (34.6–46.0) 98.2 (94.5–102.0) 93.3 (87.1–100.4)
E171 50 − 6.0 (− 6.7 to − 2.3) − 7.5 (− 7.6 to − 7.4) −7.6 (− 7.7 to − 7.4) 43.1 (35.2–131.6) 101.1 (97.6–104.7) 98.0 (92.3–104.5)
500 −6.1 (− 6.6 to − 5.1) −7.2 (− 7.4 to − 7.1) −7.6 (− 7.9 to − 7.3) 49.5 (42.4–75.0) 101.4 (96.1–107.4) 112.0* (101.9–124.7)
E153 0.64 −5.9 (− 6.2 to − 5.5) −7.1 (− 7.2 to − 6.9) −7.4 (− 7.6 to − 7.3) 34.6 (30.7–41.4) 111.1* (104.3–119.1) 101.4 (95.9–107.6)
6.4 −5.9 (− 6.4 to − 4.3) −7.5 (− 8.0 to − 7.2) −7.4 (− 7.6 to − 7.2) 40.2 (33.2–74.1) 98.9 (88.5–116.1) 111.5* (103.5–120.6)
NTG
Control 0 −7.5 (− 7.6 to − 7.4) − 5.4 (− 6.1 to − 3.0) −6.7 (− 7.1 to − 6.1) 91.0 (87.2–95.6) 153.1 (115.7–365.2) 111.1 (96.8–144.3)
E171 50 −7.5 (− 7.7 to − 7.2) − 5.2 (− 6.0 to − 0.1) −5.9 (− 6.4 to − 4.7) 89.0 (82.2–99.3) 166.2 (118.7–902.1) 143.0 (117.2–226.7)
500 −7.8* (− 8.0 to − 7.7) − 6.6 (− 7.3 to 2.6) − 6.2 (− 6.7 to − 4.9) 94.1 (90.5–98.2) 125.8 (98.9–1086.0) 115.3 (94.8–188.8)
E153 0.64 −7.8 (− 8.0 to − 7.6) − 5.0 (− 5.9 to 0.8) −6.3 (− 6.9 to − 6.1) 90.2 (85.1–96.8) 176.0 (122.9–1208.0) 126.4 (98.3–480.6)
6.4 −7.7 (− 7.9 to − 7.5) −6.2 (− 6.6 to − 5.5) −6.2 (− 7.0 to 17.1) 89.2 (83.8–96.3) 129.5 (111.4–171.2) 142.5 (107.8–26,498.0)
5-HT
Control 0 −5.2 (− 5.3 to − 5.0) − 6.2 (− 6.4 to − 6.0) − 6.0 (− 6.2 to − 5.9) 125.8 (117.7–135.4) 158.9 (147.5–171.5) 112.2 (104.4–120.9)
E171 50 −5.1 (− 5.2 to − 5.0) −6.3 (− 6.4 to − 6.1) −6.2 (− 6.4 to − 6.0) 128.4 (120.7–137.8) 152.2 (144.1–160.7) 155.4* (141.5–171.3)
500 −5.2 (− 5.4 to − 5.0) −6.2 (− 6.6 to − 5.8) −6.1 (− 6.3 to − 5.8) 113.9 (100.4–132.5) 126.9 (111.5–149.5) 113.7 (102.6–126.7)
E153 0.64 −5.0 (− 5.1 to − 4.9) − 6.3 (− 6.6 to − 5.9) −6.2 (− 6.4 to − 5.9) 130.8 (122.2–141.1) 172.4 (152.6–201.3) 115.1 (102.6–128.7)
6.4 −5.1 (− 5.3 to − 5.0) − 6.3 (− 6.6 to − 6.0) 6.1 (− 6.3 to − 5.9) 123.5 (115.2–133.6) 132.8 (119.4–148.9) 112.2 (103.9–121.9)
  1. The concentration-response curves were performed for acetylcholine (ACh), nitroglycerine (NTG) and 5-hydroxytryptamine (5-HT) on the aorta and coronary arteries from rats exposed intragastrically to E171 or E153 once a week for 10 weeks. The data are presented as mean and 95% CI. The number of animals in each group varied; specified in the concentration-response curves (Figs. 6, 7 and 8). An asterisk (*) denotes statistically significant effects when compared to the effect in the control group (P < 0.05)