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Table 5 Biochemical parameters in lean Zucker rats after repeated exposure to E171 and E153 by oral gavage

From: Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

In vivo Study Control (n = 9) E171 (n = 9) E171 (n = 10) E153 (n = 10) E153 (n = 8)
Dose (mg/kg bw/week) 0 50 500 0.64 6.4
Vitamin C (μM) (ascorbate + DHA) 19.6 ± 2.9 20.3 ± 2.6 21.0 ± 4.6 20.5 ± 3.9 18.9 ± 2.9
MDA (μM) 0.20 ± 0.05 0.19 ± 0.08 0.22 ± 0.07 0.20 ± 0.07 0.19 ± 0.05
BH4 (nM) 150.1 ± 20.4 149.2 ± 18.9 154.8 ± 43.7 151.5 ± 20.5 134.5 ± 27.4
BH4/BH2 ratio (nM) 0.20 ± 0.04 0.18 ± 0.04 0.19 ± 0.04 0.17 ± 0.05 0.21 ± 0.05
ADMA (μM) 178.1 ± 31.8 192.3 ± 41.0 179.1 ± 47.0 219.8 ± 118.1 215.1 ± 89.4
L-arginine (μM) 51.0 ± 8.8 61.8 ± 15.8 58.3 ± 16.9 75.5 ± 54.1 75.1 ± 35.5
  1. All biochemical parameters were measured in plasma samples taken at the time of sacrifice. bw: body weight, DHA dehydroascorbic acid, MDA malondialdehyde, BH4 tetrahydrobiopterin, BH2 dihydrobiopterin, ADMA asymmetric dimethylarginine. Data are represented as mean ± SD