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Table 6 Results of multiple linear regression modeling of cardiovascular metrics

From: Association of pulmonary, cardiovascular, and hematologic metrics with carbon nanotube and nanofiber exposure among U.S. workers: a cross-sectional study

 

CNT/F metric β estimate (p-value)

Systolic BPa

Diastolic BPb

Heart ratec

Exposure variable – untransformed

 EC–inhalable (μg/m3)

-2.65E-2 (0.386)

-2.85E-2 (0.213)d

8.63E-2 (0.0026)d

 EC-respirable (μg/m3)

-0.255 (0.317)d

-0.221 (0.251)

0.667 (0.0074)

 TEM-total (structures/cm3)

-0.321 (0.905)

-0.992 (0.624)

0.929 (0.688)

 CNT/F found in sputum

1.03 (0.779)

1.02 (0.712)

1.20 (0.695)

 CNT/F duration employed (years)

0.181 (0.575)

-9.46E-3 (0.968)

-0.777 (0.0029)

Exposure variable – log-transformed

 ln(EC-inhalable)

0.187 (0.653)

-5.72E-2 (0.856)

0.958 (0.0055)

 ln(EC-respirable)

-0.588 (0.331)

-0.367 (0.416)

0.190 (0.705)

 ln(TEM-total)

0.349 (0.469)

-2.59E-4 (0.999)

0.216 (0.597)

Effect modification e

 Male

-0.238

-0.0270

0.0870

 Female

-3.52

-0.241

-0.454

  p for interaction

 0.350

 0.459

 0.063

 White race, non-Hispanic

-0.259

-0.0284

0.0860

 All other races and Hispanic

-11.6

0.417

-1.81

  p for interaction

 0.398

 0.819

 0.352

 Age <40

-0.195

-5.88E-2

1.55E-2

 Age ≥40

-0.279

-2.69E-2

8.79E-2

  p for interaction

 0.881

 0.740

 0.483

 Education < college degree

-0.206

-6.38E-2

9.86E-2

 Education ≥ college degree

-0.257

-2.81E-2

8.60E-2

  p for interaction

 0.966

 0.837

 0.945

 No lung diseasef

-0.254

-7.14E-4

9.03E-2

 Has lung disease

-0.255

-2.94E-2

8.63E-2

  p for interaction

 1.00

 0.814

 0.976

 CHM score <5

-0.254

-0.0263

0.0867

 CHM score ≥5

-5.49

-0.315

-0.383

  p for interaction

 0.133

 0.309

 0.112

  1. Abbreviations—BP blood pressure, CHM cardiovascular health metric, CNT/F carbon nanotubes or nanofibers, EC elemental carbon, TEM transmission electron microscopy
  2. aSystolic BP adjusted for age, sex, and total 10-1000 nm particulate counts per cm3 (measured with condensation particle counter)
  3. bDiastolic BP adjusted for sex, cigarette pack-years, and CHM score
  4. cHeart rate adjusted for employment duration and CHM score
  5. dCNT/F exposure metric associated with the lowest Schwarz’s Bayesian Criterion value (best fit)
  6. eParameter estimates and p-values are shown for the CNT/F exposure metric identified as having the best fit
  7. fSelf-reported respiratory allergy, asthma, or COPD