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Table 2 Summary of genotoxicity results for the source NMs. The number of positives results over the total number of tests performed is indicated

From: Grouping of nanomaterials to read-across hazard endpoints: from data collection to assessment of the grouping hypothesis by application of chemoinformatic techniques

 

in vivo

in vitro

Micronucleus assay

Comet assay

Micronucleus assay

Comet assay

Genotoxicity (1/0)a

NM-100

–

–

–

2/2

1

NM-101

0/3

1/5

–

2/6

0

NM-102

0/6

2/13

3/10

5/8

1

NM-103

0/5

1/12

3/8

0/6

0

NM-104

0/5

2/12

3/8

0/6

0

NM-105

2/9

4/15

4/18

10/14

1

  1. a 1: NM is considered genotoxic in the in vitro comet assay; 0: NM is considered not genotoxic in the in vitro comet assay. The column highlighted in bold presents data used to determine the genotoxicity (1, 0) of each NM
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Particle and Fibre Toxicology

ISSN: 1743-8977

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