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Table 2 Dose metrics causing 20% loss of viability (LD20) to (bone marrow derived macrophages from wild-type C57BL/6 J mice (WT) or Scavenger Receptor A deficient mice (SR-A (−/−) or RAW 264.7 (RAW) cells after exposure to silver nanoparticles of various sizes

From: All that is silver is not toxic: silver ion and particle kinetics reveals the role of silver ion aging and dosimetry on the toxicity of silver nanoparticles

  LD20
Nanoparticle Size
(nm)
Cell Type Exposure Concentration (μg/mL) Cellular Nanoparticle Mass (μg) Cellular Nanoparticle Surface Area (cm2) Cellular Ion Mass (ng)
20 RAW 15.9 0.93 0.18 3.82
20 WT 6.25 0.18 0.06 3.21
20 SR-A(−/−) 12.7 0.09 0.03 3.67
110 RAW 19.9 0.94 0.05 3.08
110 WT 20.2 0.95 0.05 3.02
110 SR-A(−/−) 45.3 2.22 0.12 3.62
CVa (%)   67 86 70 10
  1. aCoefficient of variation (CV)