Table 2 Dose metrics causing 20% loss of viability (LD20) to (bone marrow derived macrophages from wild-type C57BL/6 J mice (WT) or Scavenger Receptor A deficient mice (SR-A (−/−) or RAW 264.7 (RAW) cells after exposure to silver nanoparticles of various sizes
| Â | LD20 | ||||
|---|---|---|---|---|---|
Nanoparticle Size (nm) | Cell Type | Exposure Concentration (μg/mL) | Cellular Nanoparticle Mass (μg) | Cellular Nanoparticle Surface Area (cm2) | Cellular Ion Mass (ng) |
20 | RAW | 15.9 | 0.93 | 0.18 | 3.82 |
20 | WT | 6.25 | 0.18 | 0.06 | 3.21 |
20 | SR-A(−/−) | 12.7 | 0.09 | 0.03 | 3.67 |
110 | RAW | 19.9 | 0.94 | 0.05 | 3.08 |
110 | WT | 20.2 | 0.95 | 0.05 | 3.02 |
110 | SR-A(−/−) | 45.3 | 2.22 | 0.12 | 3.62 |
CVa (%) | Â | 67 | 86 | 70 | 10 |