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Table 2 Silver concentration in each a lung lobe (RCr, RM, RCa, and LL) at exposed 1-day (mean ± S.D) (n = 5)

From: Lobar evenness of deposition/retention in rat lungs of inhaled silver nanoparticles: an approach for reducing animal use while maximizing endpoints

Lobes Deposition / Retention (μg/g)a Lung weight (g)b (% of total weight) Retention (μg)/lobec (% of total) Number of acinid (range) Retention (ng)/acinuse (range) No of AgNP (×106)/acinusf (range)
RCr 10.62 ± 1.80 0.10 ± 0.01 (11.1) 1.11 ± 0.23 (10.35%) 689 ± 138 (551–827) 1.61 ± 0.33 (1.28–1.94) 22.80 ± 4.65 (18.16–27.45)
RM 13.64 ± 1.68 0.11 ± 0.01 (12.2) 1.53 ± 0.26 (14.31%) 734 ± 66 (668–800) 2.09 ± 0.36 (1.73–2.45) 29.59 ± 5.06 (24.53–34.64)
RCa 11.00 ± 1.51 0.27 ± 0.03 (30) 2.91 ± 0.32 (27.10%) 1808 ± 103 (1705–1911) 1.61 ± 0.18 (1.43–1.79) 22.75 ± 2.54 (20.21–25.30)
RA 14.42 ± 1.48 0.10 ± 0.01 (11.1) 1.45 ± 0.20 (13.49%) 686 ± 89 (597–775) 2.11 ± 0.30 (1.81–2.40) 29.84 ± 4.19 (25.65–34.03)
RLg 12.02 ± 1.09 0.58 ± 0.03 (64.4) 7.00 ± 0.64 (65.25%) 3970 ± 329 (3641–4299) 1.76 ± 0.16 (1.60–1.92) 24.93 ± 2.29 (27.22–22.64)
LL 11.63 ± 1.25 0.32 ± 0.02 (35.6) 3.73 ± 0.26 (34.75%) 1973 ± 192 (1781–2165) 1.89 ± 0.13 (1.76–2.02) 26.73 ± 1.86 (24.87–28.59)
Total lung 11.88 ± 0.73 0.90 ± 0.05 10.72 ± 0.53 5943 ± 521 (5622–6264) 1.80 ± 0.09 (1.72–1.89) 25.54 ± 1.26 (24.28–26.80)
  1. Statistics analysis was three point using ANOVA that deposition, deposition amount/acinus and No of AgNP/acinus; RCr right cranial, RM right median, RCa right caudal, RA right accessory lobe, RL right lung, LL left lung; a μg/L (ICP-MS; ppb) × 0.005 L (end of volume) / lobe weight = silver concentration in 1 Gram; b Each a lobe weight; c Retained mass concentration x lung lobe weight; d Acinus number of each a lung lobe [15]; e mass retained /g of lung lobe / number of acinus (ng); f Retained mass concentration of lobe / one particle mass of AgNP (DMAS particle concentration / DMAS particle mass) / number of acinus. Single particle mass was based on CMD 19.984 nm without considering range of particle size distribution and dissolution of AgNP; g whole right lung