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Table 2 Silver concentration in each a lung lobe (RCr, RM, RCa, and LL) at exposed 1-day (mean ± S.D) (n = 5)

From: Lobar evenness of deposition/retention in rat lungs of inhaled silver nanoparticles: an approach for reducing animal use while maximizing endpoints

Lobes

Deposition / Retention (μg/g)a

Lung weight (g)b (% of total weight)

Retention (μg)/lobec (% of total)

Number of acinid (range)

Retention (ng)/acinuse (range)

No of AgNP (×106)/acinusf (range)

RCr

10.62 ± 1.80

0.10 ± 0.01 (11.1)

1.11 ± 0.23 (10.35%)

689 ± 138 (551–827)

1.61 ± 0.33 (1.28–1.94)

22.80 ± 4.65 (18.16–27.45)

RM

13.64 ± 1.68

0.11 ± 0.01 (12.2)

1.53 ± 0.26 (14.31%)

734 ± 66 (668–800)

2.09 ± 0.36 (1.73–2.45)

29.59 ± 5.06 (24.53–34.64)

RCa

11.00 ± 1.51

0.27 ± 0.03 (30)

2.91 ± 0.32 (27.10%)

1808 ± 103 (1705–1911)

1.61 ± 0.18 (1.43–1.79)

22.75 ± 2.54 (20.21–25.30)

RA

14.42 ± 1.48

0.10 ± 0.01 (11.1)

1.45 ± 0.20 (13.49%)

686 ± 89 (597–775)

2.11 ± 0.30 (1.81–2.40)

29.84 ± 4.19 (25.65–34.03)

RLg

12.02 ± 1.09

0.58 ± 0.03 (64.4)

7.00 ± 0.64 (65.25%)

3970 ± 329 (3641–4299)

1.76 ± 0.16 (1.60–1.92)

24.93 ± 2.29 (27.22–22.64)

LL

11.63 ± 1.25

0.32 ± 0.02 (35.6)

3.73 ± 0.26 (34.75%)

1973 ± 192 (1781–2165)

1.89 ± 0.13 (1.76–2.02)

26.73 ± 1.86 (24.87–28.59)

Total lung

11.88 ± 0.73

0.90 ± 0.05

10.72 ± 0.53

5943 ± 521 (5622–6264)

1.80 ± 0.09 (1.72–1.89)

25.54 ± 1.26 (24.28–26.80)

  1. Statistics analysis was three point using ANOVA that deposition, deposition amount/acinus and No of AgNP/acinus; RCr right cranial, RM right median, RCa right caudal, RA right accessory lobe, RL right lung, LL left lung; a μg/L (ICP-MS; ppb) × 0.005 L (end of volume) / lobe weight = silver concentration in 1 Gram; b Each a lobe weight; c Retained mass concentration x lung lobe weight; d Acinus number of each a lung lobe [15]; e mass retained /g of lung lobe / number of acinus (ng); f Retained mass concentration of lobe / one particle mass of AgNP (DMAS particle concentration / DMAS particle mass) / number of acinus. Single particle mass was based on CMD 19.984 nm without considering range of particle size distribution and dissolution of AgNP; g whole right lung