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Table 3 Silver concentration in each a lung lobe (RCr, RM, RCa, RA and LL) at exposed 5-day (mean ± S.D) (n = 5)

From: Lobar evenness of deposition/retention in rat lungs of inhaled silver nanoparticles: an approach for reducing animal use while maximizing endpoints

Lobes Retention (μg/g)a Lung weight (g)b (% of total weight) Retention (μg)/lobec Number of acinid (range) Retention (ng)/acinuse (range) No of AgNP (×106)/acinusf (range)
RCr 28.41 ± 3.88 0.15 ± 0.01 (11.1) 4.22 ± 0.84 (11.27%) 689 ± 138 (551–827) 6.13 ± 1.22 (4.91–7.35) 86.78 ± 17.22 (69.56–104.00)
RM 36.21 ± 2.68 0.15 ± 0.01 (12.2) 5.58 ± 0.60 (14.88%) 734 ± 66 (668–800) 7.59 ± 0.81 (6.78–8.41) 107.54 ± 11.53 (96.01–119.07)
RCa 31.18 ± 3.14 0.35 ± 0.01 (30) 10.89 ± 0.82 (29.06%) 1808 ± 103 (1705–1911) 6.02 ± 0.46 (5.57–6.48) 85.27 ± 6.42 (78.84–91.69)
RA 36.82 ± 5.01 0.13 ± 0.02 (11.1) 4.89 ± 0.50 (13.4%) 686 ± 89 (597–775) 7.13 ± 0.72 (6.40–7.85) 100.87 ± 10.27 (90.60–111.13)
RLg 32.59 ± 2.01 0.79 ± 0.04 (64.4) 25.58 ± 1.43 (68.26%) 3970 ± 329 (3641–4299) 6.44 ± 0.36 (6.08–6.80) 96.25 ± 5.06 (96.25–86.13)
LL 26.80 ± 7.68 0.45 ± 0.03 (35.6) 11.90 ± 3.02 (31.74%) 1973 ± 192 (1781–2165) 6.03 ± 1.53 (4.50–7.56) 85.35 ± 21.64 (63.72–106.99)
Total lung 30.49 ± 3.81 1.23 ± 0.07 37.47 ± 3.51 5943 ± 521 (5622–6264) 6.30 ± 0.59 (5.72–6.89) 89.26 ± 8.36 (80.90–97.62)
  1. Statistics analysis was three point using ANOVA that deposition, deposition amount/acinus and No of AgNP/acinus; RCr right cranial, RM right median, RCa right caudal, RA right accessory lobe, RL right lung, LL left lung; a μg/L (ICP-MS; ppb) × 0.005 L (end of volume) / lobe weight = silver concentration in 1 Gram; b Each a lobe weight; c Retained mass concentration x lung lobe weight; d Acinus number of each a lung lobe [15]; e mass retained /g of lung lobe / number of acinus (ng); f Retained mass concentration of lobe / one particle mass of AgNP (DMAS particle concentration / DMAS particle mass) / number of acinus. Single particle mass was based on CMD 19.984 nm without considering range of particle size distribution and dissolution of AgNP; g whole right lung