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Table 3 Silver concentration in each a lung lobe (RCr, RM, RCa, RA and LL) at exposed 5-day (mean ± S.D) (n = 5)

From: Lobar evenness of deposition/retention in rat lungs of inhaled silver nanoparticles: an approach for reducing animal use while maximizing endpoints

Lobes

Retention (μg/g)a

Lung weight (g)b (% of total weight)

Retention (μg)/lobec

Number of acinid (range)

Retention (ng)/acinuse (range)

No of AgNP (×106)/acinusf (range)

RCr

28.41 ± 3.88

0.15 ± 0.01 (11.1)

4.22 ± 0.84 (11.27%)

689 ± 138 (551–827)

6.13 ± 1.22 (4.91–7.35)

86.78 ± 17.22 (69.56–104.00)

RM

36.21 ± 2.68

0.15 ± 0.01 (12.2)

5.58 ± 0.60 (14.88%)

734 ± 66 (668–800)

7.59 ± 0.81 (6.78–8.41)

107.54 ± 11.53 (96.01–119.07)

RCa

31.18 ± 3.14

0.35 ± 0.01 (30)

10.89 ± 0.82 (29.06%)

1808 ± 103 (1705–1911)

6.02 ± 0.46 (5.57–6.48)

85.27 ± 6.42 (78.84–91.69)

RA

36.82 ± 5.01

0.13 ± 0.02 (11.1)

4.89 ± 0.50 (13.4%)

686 ± 89 (597–775)

7.13 ± 0.72 (6.40–7.85)

100.87 ± 10.27 (90.60–111.13)

RLg

32.59 ± 2.01

0.79 ± 0.04 (64.4)

25.58 ± 1.43 (68.26%)

3970 ± 329 (3641–4299)

6.44 ± 0.36 (6.08–6.80)

96.25 ± 5.06 (96.25–86.13)

LL

26.80 ± 7.68

0.45 ± 0.03 (35.6)

11.90 ± 3.02 (31.74%)

1973 ± 192 (1781–2165)

6.03 ± 1.53 (4.50–7.56)

85.35 ± 21.64 (63.72–106.99)

Total lung

30.49 ± 3.81

1.23 ± 0.07

37.47 ± 3.51

5943 ± 521 (5622–6264)

6.30 ± 0.59 (5.72–6.89)

89.26 ± 8.36 (80.90–97.62)

  1. Statistics analysis was three point using ANOVA that deposition, deposition amount/acinus and No of AgNP/acinus; RCr right cranial, RM right median, RCa right caudal, RA right accessory lobe, RL right lung, LL left lung; a μg/L (ICP-MS; ppb) × 0.005 L (end of volume) / lobe weight = silver concentration in 1 Gram; b Each a lobe weight; c Retained mass concentration x lung lobe weight; d Acinus number of each a lung lobe [15]; e mass retained /g of lung lobe / number of acinus (ng); f Retained mass concentration of lobe / one particle mass of AgNP (DMAS particle concentration / DMAS particle mass) / number of acinus. Single particle mass was based on CMD 19.984 nm without considering range of particle size distribution and dissolution of AgNP; g whole right lung