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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials

Fig. 5

TEM/STEM micrographs of 16HBE14o-/DTHP-1 lung co-culture model following treatment with dSPION – (a) – inverted contrast HAADF STEM image of γ-Fe2O3 internalised within DTHP-1 macrophage on top of a 16HBE14o- epithelium cellular layer – region in red box in shown in (b) and higher magnification bright field TEM shown in (c); note the ~ 90o clockwise rotation of the TEM image. (d) - STEM image of γ-Fe2O3 internalised by 16HBE14o-, cell region highlighted by red box is shown in (e) and higher magnification TEM is shown in (f); TEM image is rotated clockwise relative to STEM image. (g) - STEM image of Fe3O4 within DTHP-1 macrophage within the co-culture – region in red box in shown in (h) and high magnification TEM shown in (i)

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Particle and Fibre Toxicology

ISSN: 1743-8977

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