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Fig. 9 | Particle and Fibre Toxicology

Fig. 9

From: Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

Fig. 9

The role of SiNPs-triggered miR-451a on IL6R/STAT/TF signaling pathway in vitro by miR-451a mimics/inhibitor. The expressions of miR-451a, IL6R, JAK1, STAT3, TF, FGA, FGB and FGG (a-h) were measured in HUVECs. The results of plasmid transfection with miR-451a mimics/inhibitor on IL6R/STAT/TF pathway (i). The protein levels of IL6R, JAK1, STAT3, TF and FIB were caculated by the relative densitometric analysis (j). Data are expressed as means ± S.D. from three independent experiments. *p < 0.05 and **p < 0.01 compared with control without SiNPs and any mimics/inhibitor

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