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Table 3 Comparison of significant pathways from the RNA-seq dataset using gene set tests on GSE14288, a microarray analysis of mouse neonatal cardiomyocytes overexpressing CHF1/Hey2 and treated with serum to induce hypertrophy. The # Genes column reflects the number of genes in the microarray data that were tested, and the FDR is the Benjamini-Hochberg adjusted p-value for the test that, on average, the genes in the set are differentially expressed

From: In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation

Ingenuity Canonical Pathway

# Genes

FDR

Mitochondrial L-carnitine Shuttle Pathway

11

5.92E-06

Fatty Acid β-oxidation

23

6.26E-15

AMPK Signaling

566

1.02E-23

Cell Cycle Control of Chromosomal Replication

48

4.64E-16

LPS/IL-1 Mediated Inhibition of RXR Function

169

2.31E-30

GADD45 Signaling

24

1.00E-08

Hepatic Fibrosis/Hepatic Stellate Cell Activation

179

3.68E-20

Ketogenesis

8

1.46E-06

Estrogen-mediated S-phase Entry

44

1.01E-19

Oleate Biosynthesis II (Animals)

8

3.56E-06