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Fig. 8 | Particle and Fibre Toxicology

Fig. 8

From: Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Fig. 8

Influence of NP on release of TGF-β isoforms in BrainSpheres. Graphs show the levels of secreted TGF-β1, TGF-β2 and TGF-β3 after exposure to Au-SC (6 μg/mL), Au-PEG (20 μg/mL) and PLA-NP (20 μg/mL) for 24 and 72 h in comparison to untreated control spheroids. Each experimental group corresponds to the analysis of three independent experiments with three replicates and represents mean (± SEM). One-way ANOVA with Bonferroni’s multiple comparisons post-test was used to analyze the statistical significance (*p < 0.05, ***p < 0.001)

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